Copper Toxicosis (Attenuating)

Clinical

The ATP7A variant is considered beneficial and may be best described as a helpful modifier of the harmful copper toxicosis variant ATP7B. The ATP7A variant may help mitigate some of the symptoms of dogs with variants at ATP7B. Dogs with the ATP7A variant have not been observed to have any beneficial or harmful complications if they have two copies of the normal ATP7B variant.

  • Signs and symptoms

    There should be no clinical signs associated with this variant. This variant may help mitigate clinical signs in dogs with the ATP7B accumulating variant. If your dog has the ATP7B variant, please read about possible clinical signs on the ATP7B page.

    A variant in this gene may delay or have no effect on the onset of clinical signs of copper toxicosis in dogs with the ATP7B variant. If your dog has the ATP7B variant, please read more about the age of onset on the ATP7B page.

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  • Diagnosis

    No diagnostics are required for this variant. If your dog has the ATP7B variant, please read what diagnostics may be considered on the ATP7B page.

  • Treatment

    No treatment is required for this variant. If your dog has the ATP7B variant, please read the available treatment on the ATP7B page.

  • What to do if your dog is at risk

    Actions

    • No actions are required for dogs with this variant. If your dog has the ATP7B variant, please read what actions you can take on the ATP7B page.

  • Genetic Information

    This mutation was first described in the Labrador Retriever. However, it has recently been studied in the Doberman Pinscher and may also benefit this breed.

    This variant has a complex inheritance. This variant has been shown to decrease copper accumulation in dogs with one or two copies of the ATP7B variant but is more effective in male dogs. However, this variant is not completely protective in either sex.

    Gene names:

    ATP7A ‐ chr

    Inheritance type:

    complex

  • Breeds affected

    This health condition affects the following breeds

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