Limb-Girdle Muscular Dystrophy 2D
Muscular dystrophy is a degenerative disorder characterized by progressive muscular dysfunction. This variant in the SGCA gene causes Limb-Girdle Muscular Dystrophy 2D (LGMD 2D) in young adult dogs. Clinical signs can vary in severity and include muscle weakness, exercise intolerance, and difficulty swallowing.
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Signs and symptoms
Clinical signs include exercise intolerance, progressive weakness, a stiff gait, and difficulty swallowing (dysphagia). Some animals may appear clinically unaffected, and the condition is suspected based on “incidental” blood work findings.
This condition is likely present from birth, but you may not observe signs until the dog is 7-17 months of age.Uncover health risks with Embark
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Diagnosis
Genetic testing, clinical signs, and muscle biopsy can be used to diagnose LGMD. Your vet may perform specific blood tests on the basis of this result.
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Treatment
At this time, care is only able to help with symptoms, and recommendations vary based on the clinical severity of the disease.
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What to do if your dog is at risk
Actions
- Slings can be used to assist with dogs' mobility, and caution should be taken to avoid falling hazards.
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Genetic Information
This variant was first identified in Miniature Dachshunds.
This variant has an autosomal recessive inheritance, meaning that dogs must have two copies of the variant in order to show clinical signs of LGMD from it.
Gene names:
SGCA Exon 3 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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