Copper Toxicosis (Attenuating)
The RETN variant is considered beneficial and may be best described as a helpful modifier of the harmful copper toxicosis variant ATP7B. The RETN variant may help mitigate some of the symptoms of dogs with variants at ATP7B. Dogs with the RETN variant have not been observed to have any beneficial or harmful complications if they have two copies of the normal ATP7B variant.
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Signs and symptoms
There should be no clinical signs associated with this variant. This variant may help mitigate clinical signs in dogs with the ATP7B accumulating variant. If your dog has the ATP7B variant, please read about possible clinical signs on the ATP7B page.
A variant in this gene may delay or not affect the onset of clinical signs of copper toxicosis in dogs with the ATP7B variant. If your dog has the ATP7B variant, please read more about the age of onset on the ATP7B page. -
Diagnosis
No diagnostics are required for this variant. If your dog has the ATP7B variant, please read what diagnostics may be considered on the ATP7B page.
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Treatment
No treatment is required for this variant. If your dog has the ATP7B variant, please read the available treatment on the ATP7B page.
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What to do if your dog is at risk
Actions
- No actions are required for dogs with this variant. If your dog has the ATP7B variant, please read what actions you can take on the ATP7B page.
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Genetic Information
This mutation was first described in the Labrador Retriever.
This variant has a complex inheritance. This variant may decrease copper accumulation in dogs with one or two copies of the ATP7B variant, but should not be considered fully protective.
Gene names:
RETN Exon 2 ‐ chr
Inheritance type:
complex
Citations:
Wu et al 2020 , Feiten et al 2016 , Wu et al 2019 , Langlois et al 2022
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Breeds affected
This health condition affects the following breeds
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