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Integument

This is a Skin & Connective Tissues condition.

Dystrophic Epidermolysis Bullosa

What is Dystrophic Epidermolysis Bullosa?

This skin disorder gives affected dogs skin that stretches and tears easily; affected dogs must be monitored closely and treated promptly for any injuries. It arises from a mutation in Collagen Type VII. Collagens of all types anchor the layers of our skin together: they are what gives skin its springy, youthful texture (and thus are a big component of anti-wrinkle creams). Collagen Type VII has the specific job of connecting the epidermis, the surface layer of the skin, to the underlying tissues, leading to dogs with especially stretchy skin that is easily detached from the underlying tissues. A variety of therapies, including skin grafts, stem cell therapy, and gene therapy, are under investigation for the treatment and prevention of EB, but these are young in development.

What are the signs & symptoms that develop in affected dogs?

Affected dogs have skin that is injured easily and stretches more than normal.

When do signs and symptoms develop?

Signs first appear in puppies.

How do vets diagnose this condition?

Genetic testing, skin biopsy, and clinical signs can be used to diagnose this condition.

How is this condition treated?

A variety of therapies, including skin grafts, stem cell therapy, and gene therapy, are under investigation for the treatment and prevention of EB, but these are young in development.

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