Inherited Selected Cobalamin Malabsorption with Proteinuria
This is a gastrointestinal disease where dogs cannot absorb cobalamin, often causing them to be small with poor energy levels. Cobalamin is required for synthesis of certain amino acids and is an important factor for a number of other metabolic processes. Dogs cannot generate their own cobalamin but must consume it in their diet. However, dogs with IGS cannot absorb cobalamin from their meals.
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Signs and symptoms
Affected puppies are usually runty and have poor energy levels. If not caught at this time, signs can progress to vomiting and seizures.
Signs first appear in puppies.Uncover health risks with Embark
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Diagnosis
Laboratory testing will show a low red blood cell count. On physical exam, an abnormally slow heart rate will be noted. Genetic testing, clinical signs and additional blood tests are used to diagnose this disorder.
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Treatment
Fortunately, IGS is treatable with regular injections of cobalamin. Early treatment is associated with the best outcome.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s cobalamin malabsorption result so you can plan regular monitoring, vitamin B12 supplementation if needed, and routine checkups to ensure vitamin levels stay stable.
- Watch for signs such as poor appetite, weight loss, lethargy, or pale gums, and contact your vet if you notice any of these changes.
- With consistent care and supplementation, most dogs with this condition can live relatively normal, active lives.
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Genetic Information
This mutation was first described in Komondors.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
CUBN ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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