Pituitary Dwarfism
This variant in the POU1F1 gene causes proportionately small stature and coat abnormalities. Affected dogs are typically hypothyroid as well.
-
Signs and symptoms
Affected dogs will have a proportionately small stature and coat abnormalities including a puppy-like (lanugo) coat that lacks most primary or guard hairs. The skin may appear thin and dark (hyperpigmented) with signs of inflammation. Dogs may experience gradual hair loss and delayed or absent tooth development. There may also be reproductive abnormalities.
Clinical signs may be visible as early as a few weeks of life, but coat abnormalities and small size may not be clear until puppies are older. Affected dogs may need to be intensively nursed and hand-reared, which may lead to hypopituitarism being undiagnosed and labeled as “failure to thrive.”Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $118
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
Clinical history, genetic testing, and laboratory testing can be used in conjunction to diagnose Pituitary Dwarfism. Because this form of Pituitary Dwarfism is the result of combined pituitary hormone deficiency, in most affected dogs there is also secondary hypothyroidism.
-
Treatment
One or more hormones may require supplementation as prescribed by your veterinarian.
-
What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s pituitary dwarfism result so you can discuss potential hormone deficiencies and the best plan for ongoing monitoring and treatment.
- Some dogs with this condition may remain small but otherwise live comfortably with proper care and regular check-ins.
- Provide a calm environment and consistent daily routines to support your dog’s energy and comfort.
- Feed a balanced diet appropriate for their size and activity level, and monitor for any changes in coat quality, appetite, or activity that could indicate a hormonal imbalance.
-
Genetic Information
This variant was first identified in Karelian Bear Dogs.
Pituitary Dwarfism is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the variant to show clinical signs from it.
Gene names:
POU1F1 Intron 4 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
