Platelet Factor X Receptor Deficiency, Scott Syndrome


Canine Scott Syndrome is a defect in platelet function leading to impaired secondary hemostasis. Secondary hemostasis occurs after a platelet "plug" has formed. Its role is to make the plug stable by adding fibrin to the clot. Dogs with CSS have platelets that cannot signal in response to stimuli to induce platelet activation or death.

  • Signs and symptoms

    If your affected dog suffers a major trauma or undergoes surgery, they may not be able to clot well leading to increased blood loss or internal bleeding.

    Dogs are born with this condition.

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  • Diagnosis

    Genetic and laboratory testing can be used to diagnose this disorder.

  • Treatment

    There is no cure for this condition. Dogs with this disease may need blood/platelet transfusions during surgery or following a major trauma. However, they should have a normal lifespan.

  • What to do if your dog is at risk


    • Plan major surgeries with your veterinarian in advance and inform them of your dog’s potential for bleeding.

  • Genetic Information

    This mutation was first identified in the German Shepherd Dog.

    This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

    Gene names:

    TMEM16F ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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