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Hematologic

This is a Blood condition.

Platelet factor X receptor deficiency, Scott Syndrome

What is Scott Syndrome?

Canine Scott Syndrome is a defect in platelet function leading to impaired secondary hemostasis. Secondary hemostasis occurs after a platelet "plug" has formed. Its role is to make the plug stable by adding fibrin to the clot. Dogs with CSS have platelets that cannot signal in response to stimuli to induce platelet activation or death. This mutation was first identified in the German Shepherd Dog. This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected. Dogs are born with this condition. If your affected dog suffers a major trauma or undergoes surgery, they may not be able to clot well leading to increased blood loss or internal bleeding. Genetic and laboratory testing can be used to diagnose this disorder. There is no cure for this condition. Dogs with this disease may need blood/platelet transfusions during surgery or following a major trauma. However, they should have a normal lifespan. Plan major surgeries with your veterinarian in advance and inform them of your dog’s potential for bleeding.

What are the signs & symptoms that develop in affected dogs?

If your affected dog suffers a major trauma or undergoes surgery, they may not be able to clot well leading to increased blood loss or internal bleeding.

When do signs and symptoms develop?

Dogs are born with this condition.

How do vets diagnose this condition?

Genetic and laboratory testing can be used to diagnose this disorder.

How is this condition treated?

There is no cure for this condition. Dogs with this disease may need blood/platelet transfusions during surgery or following a major trauma. However, they should have a normal lifespan.

What actions should I take if my dog is affected?

Plan major surgeries with your veterinarian in advance and inform them of your dog’s potential for bleeding.

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