This is a Kidney and Bladder condition.

Primary Hyperoxaluria

What is Primary Hyperoxaluria?

Primary hyperoxaluria is caused by a mutation in the the AGXT genes. Loss of the enzyme product of AGXT, alanine-glycoxylate aminotransferase, causes an inability to break down glyoxylate leading to the formation of oxalate-based stones in the kidney and bladder.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have excessive thirst and urination and strain while urinating. If in kidney failure, they may not be able to produce urine, vomit, and be lethargic.

When do signs and symptoms develop?

Signs are often first noted in puppies.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnosis this disorder.

How is this condition treated?

If diagnosed early, this disorder can be managed with dietary and lifestyle changes. However, if a puppy presents in kidney failure, aggressive treatment including hospitalization will be required and the puppy will have a poor prognosis.

What actions should I take if my dog is affected?

  • Closely monitoring your dog's urination habits, routine lab work, and following your veterinarian's nutritional advice are the best ways to keep your dog healthy.
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