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This is a Kidney and Bladder condition.

Oxalate Kidney & Bladder Stones

What is Oxalate Kidney & Bladder Stones?

First characterized in the Coton de Tulear, this condition leads to the formation of oxalate and calcium oxalate stones and, if diagnosed early, can be managed with dietary and lifestyle changes. Early diagnosis of this condition is key: historically, affected dogs present as puppies in renal failure, a situation that requires emergency care and carries a poor prognosis. In the Coton de Tulear, primary hyperoxaluria is caused by a mutation in the the AGXT genes. Loss of the enzyme product of AGXT, alanine-glycoxylate aminotransferase, causes an inability to break down glyoxylate leading to the formation of oxalate-based stones in the kidney and bladder. These are toxic to the kidney and if left diagnosed can cause renal failure, which is characterized by the inability to produce urine, vomiting, and lethargy/neurologic behavior.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have excessive thirst and urination and strain while urinating. If in kidney failure, they may not be able to produce urine, vomit, and be lethargic.

When do signs and symptoms develop?

Signs are often first noted in puppies.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnosis this disorder.

How is this condition treated?

If diagnosed early, this disorder can be managed with dietary and lifestyle changes. However, if a puppy presents in kidney failure, aggressive treatment including hospitalization will be required and the puppy will have a poor prognosis.