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Thrombopathia

Blood

Thrombopathia is a type of platelet coagulopathy, a disorder of blood clotting. Dogs with this disorder can bleed spontaneously from their nose (epistaxis), gums (gingiva), and even under their skin (petechiae).

  • Signs and symptoms

    Affected puppies may bleed abnormally when teething. You may notice extensive bruising or bleeding that does not stop following a traumatic event. Dogs may spontaneously bleed from their nose or gums or have dark purple discoloration of their skin.

    This disease is typically diagnosed in puppies or young adults when they are spayed or neutered and have a problem with clotting. However, it can be diagnosed at any age.

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  • Diagnosis

    Genetic or laboratory tests are performed to diagnose this condition.

  • Treatment

    Currently, treatment for thrombopathia focuses on prevention, vigilant monitoring, and quick treatment of spontaneous bleeds. Dogs with thrombopathia are at great risk for uncontrollable bleeding during surgical procedures: your veterinarian should be informed so that appropriate blood products are at hand in case a transfusion is required.

  • What to do if your dog is at risk

    Actions

    • Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a catastrophic outcome.
    • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.

  • Genetic Information

    This variant was first identified in Basset Hounds.

    Thrombopathia is inherited in an autosomal recessive manner, meaning that a dog must possess two copies of the mutation to show clinical signs of the disease.

    Gene names:

    RASGRP1 Exon 5 ‐ chr

    Inheritance type:

    recessive

    Citations:

    Boudreaux et al 2007

  • Breeds affected

    This health condition affects the following breeds

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