This is a Clinical condition.

Multiple Drug Sensitivity

What is MDR1?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

What are the signs & symptoms that develop in affected dogs?

MDR1 often presents in young adulthood, only because this is most commonly when a dog is first exposed to a problem drug like high dose ivermectin or acepromazine.

When do signs and symptoms develop?

Symptoms arise after a dog has received an MDR1 problem drug or dosage, and can range from vomiting and diarrhea to lethargy, seizures, or coma.

How do vets diagnose this condition?

This is usually a retroactive diagnosis after a dog has an adverse reaction to a problem drug--however, genetic testing could help you avoid a first reaction altogether.

How is this condition treated?

MDR1 is perfectly avoidable simply by avoiding the problem drugs, or problem dosages.

What actions should I take if my dog is affected?

  • Review the MDR1 Problem Drug List as described by Washington State University and notify your veterinarian to flag this in your dog’s file!
  • Farm dogs with MDR1 may also benefit if they are either kept away from herds where ivermectin is used as a routine antiparasitic, or if another form of antiparasitic is used in areas that they are working.
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