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Urinary

This is a Kidney and Bladder condition.

2-DHA Kidney & Bladder Stones

What is 2,8-DHA Urolithiasis?

This condition causes 2,8-dihydroxyadenine (2,8-DHA) kidney and bladder stones: if caught early, it can be medically managed. 2,8-DHA urolithiasis is hard to diagnose early: often the only sign is that your dog’s urine may have a dark tinge to it. If the stones are allowed to get larger, your dog may have difficulty urinating, or may need to urinate all the time due to chronic bladder irritation. 2,8-DHA is also toxic to the kidneys and, if left undiagnosed and unmanaged, can lead to kidney failure. Because 2,8-DHA stones are invisible on X-rays, diagnosis of the urolithiasis is typically made by ultrasound. Confirmation that the stones are 2,8-DHA must be made by analysis of the stones themselves. Treatment includes surgical removal or ablation of existing stones if they are interfering with your dog’s ability to urinate. However, early diagnosis of 2,8-DHA followed by a low purine diet, medications that reduce purine synthesis, and close monitoring can reduce the occurrence of stones and improve your dog's quality of life.

What are the signs & symptoms that develop in affected dogs?

If caught early, it can be medically managed. However, 2,8-DHA urolithiasis is hard to diagnose early because the only sign is dark tinged urine. If the stones are allowed to get larger, your dog may have difficulty urinating, or may need to urinate all the time due to chronic bladder irritation. 2,8-DHA is also toxic to the kidneys and can lead to kidney failure.

When do signs and symptoms develop?

Signs typically develop in adult dogs when stones have had the chance to develop.

How do vets diagnose this condition?

The stones are not visible on radiographs, so ultrasound is required to visualize them. The stones must then be analyzed by a lab. Genetic testing is another way to detect the condition.

How is this condition treated?

Treatment includes surgical removal or ablation of existing stones if they are interfering with your dog’s ability to urinate.

What actions should I take if my dog is affected?

A low purine diet, medications that reduce purine synthesis, and close monitoring can reduce the occurrence of stones and improve your dog's quality of life.

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