2-DHA Kidney & Bladder Stones

Kidney and Bladder

This condition causes 2,8-dihydroxyadenine (2,8-DHA) kidney and bladder stones.

  • Signs and symptoms

    If caught early, it can be medically managed. However, 2,8-DHA urolithiasis is hard to diagnose early because the only sign is dark tinged urine. If the stones are allowed to get larger, your dog may have difficulty urinating, or may need to urinate all the time due to chronic bladder irritation. 2,8-DHA is also toxic to the kidneys and can lead to kidney failure.

    Signs typically develop in adult dogs when stones have had the chance to develop.

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  • Diagnosis

    The stones are not visible on radiographs, so ultrasound is required to visualize them. The stones must then be analyzed by a lab. Genetic testing is another way to detect the condition.

  • Treatment

    Treatment includes surgical removal or ablation of existing stones if they are interfering with your dog’s ability to urinate.

  • What to do if your dog is at risk


    • A low purine diet, medications that reduce purine synthesis, and close monitoring can reduce the occurrence of stones and improve your dog's quality of life.

  • Genetic Information

    This mutation was first described in Native American Indian Dogs and one mixed breed.

    This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

    Gene names:

    APRT (Exon 3) ‐ chr5

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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