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This is a Clinical condition.

ALT Activity

What is ALT Activity?

The liver enzyme alanine aminotransferase, or ALT, is one of several values your veterinarian measures on routine blood work to gauge liver health. Dogs with one or more copies of the "A" allele are likely to have a lower baseline ALT activity ("low normal") than dogs with zero copies of the "A" allele ("normal"). This means that your veterinarian may recommend blood work to establish an individualized baseline ALT value during an annual wellness exam or before starting certain medications. You and your veterinarian would then be able to monitor your dog for any deviation from this established baseline. Please note that this mutation should never cause an increase in your dog’s ALT activity and does not cause liver disease. If your dog has high ALT activity, please consult your veterinarian.

What are the signs & symptoms that develop in affected dogs?

Dogs do not show any outward signs when they have this clinical trait.

How do vets diagnose this condition?

Genetic testing is the only way to provide your veterinarian with this clinical tool.

How is this condition treated?

Veterinarians may recommend blood work to establish a baseline ALT value for healthy dogs with one or two copies of this variant.