Canine Fucosidosis
A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. Fucosidosis is specifically a buildup of fucose-containing sugar and sugar derivatives. This form of lysosomal storage disease causes progressive neurologic signs.
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Signs and symptoms
Common signs of fucosidosis include progressive central nervous system malfunction, difficulty eating, subsequent weight loss, partial or total vision loss, behavior changes, abnormal gait, and seizures.
Onset of signs is typically between 1 and 4 years of age. -
Diagnosis
Genetic and laboratory testing are used to diagnose this condition. MRI or CT scans may be recommended to rule out other neurologic diseases.
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Treatment
There is no treatment for fucosidosis, and it is a fatal disease.
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What to do if your dog is at risk
Actions
- Focus on palliative therapies to increase your dog's comfort and quality of life.
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Genetic Information
This mutation was first described in the English Springer Spaniel.
This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.
Gene names:
FUCA1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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