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This is a Muscular condition.

Centronuclear Myopathy, CNM

What is Centronuclear Myopathy, CNM?

This muscle disorder is characterized by exercise intolerance, weight loss, and muscle wasting. CNM stems from a mutation in the PTPLA gene which codes for an enzyme important for a number of cellular processes. Loss of PTPLA function is thought to cause muscle fiber damage and death, leading to replacement of the muscle mass with scar tissue.

What are the signs & symptoms that develop in affected dogs?

Signs include muscle weakness, wasting, and loss of muscle control leading to difficulty walking, eating and even breathing.

When do signs and symptoms develop?

While abnormal tendon reflexes can be observed as early as 1 month, the symptoms of exercise intolerance and weight loss can be observed by 2 to 4 months of age.

How do vets diagnose this condition?

Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.

How is this condition treated?

There is no treatment for CNM, and most owners opt for euthanasia due to poor quality of life.

What actions should I take if my dog is affected?

  • Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.
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