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Immunologic

This is a Immune condition.

Complement 3 Deficiency, C3 Deficiency

What is C3 Deficiency?

Dogs affected with this disease are highly susceptible to infections and kidney disease and must be monitored closely. Activation of the C3 protein triggers a "complement cascade," a form of immune defense, which tries to trap and tag invading microbes for destruction by immune cells. In the absence of functional C3, the cascade never begins. As such, affected dogs present to the vet for recurrent bacterial infections. C3-deficient dogs are also at high risk for chronic kidney disease, thought to arise from improper regulation of the complement proteins.

What are the signs & symptoms that develop in affected dogs?

Affected dogs have recurrent bacterial infections that can affect any part of their body. Skin and respiratory infections most commonly occur. When kidney disease develops, increased thirst (polydipsia), increased urination (polyuria), and decreased appetite are often observed.

When do signs and symptoms develop?

Signs often first appear in puppies, and will continue throughout their life.

How do vets diagnose this condition?

Genetic and laboratory testing along with clinical signs are used to diagnose this disease.

How is this condition treated?

Appropriate antibiotic therapy when infections occur and consistent monitoring of kidney parameters are the key to managing this condition. Once kidney disease begins, prescription diets and fluid therapy are required. There is no cure for this disease.

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