Congenital Hypothyroidism


This a medically manageable condition that arises from an inherent inability to produce the hormone thyroxine (T4). This hormone has many roles in the body, from the skeleton to the brain, due to its role in metabolism.

  • Signs and symptoms

    Congenitally hypothyroid pups are usually lethargic and overweight with a characteristic "tragic" facial expression due to increased water retention in the facial folds. They may also present with dwarfism of the long bones and spine as well as delayed mental development. Abdominal hair loss, as well as a characteristic goiter, which is actually an enlarged thyroid gland attempting to produce thyroxine (to no avail), are also common.

    Signs first develop in puppyhood and continue throughout their lives if untreated.

    Uncover health risks with Embark

    Embark Breed + Health Test

    Original price:


    Sale price:



    Embark for Breeders Dog DNA Test

    $129 - $159


  • Diagnosis

    Genetic and laboratory testing along with clinical signs are used to diagnose this disease.

  • Treatment

    Hypothyroidism is a lifetime condition and can be managed medically with thyroxine supplementation. If untreated, dogs can enter a rare condition known as myxedema coma, where lethargy can progress to a comatose state and have a reduced heart rate, breathing rate, and low body temperature. This is an emergency situation that requires intensive care.

  • What to do if your dog is at risk


    • Early diagnosis, consistent treatment, and regular blood work are key to managing this condition well.

  • Genetic Information

    This mutation was first described in Tenterfield Terriers.

    This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

    Gene names:

    TPO ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

Learn about your dog’s unique genetic health

Dog owners

Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.

Learn about the report for dog owners
Shop the test
Breeding programs

Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.

Learn about the report for breeders
Shop the test