Congenital Myasthenic Syndrome, CMS
This is a disease characterized by episodes of severe exercise intolerance and weakness.
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Signs and symptoms
Affected puppies can usually play or run for up to a half hour, after which their strides get progressively shorter and the dog collapses. After resting, the puppy appears normal again.
Signs first appear in puppies, typically starting at 6 weeks of age. -
Diagnosis
Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.
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Treatment
CMS is a lifelong condition and affected puppies may become refractory to medication used to help treat the acquired form of this condition.
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What to do if your dog is at risk
Actions
- Minimizing intense exercise may help reduce clinical signs. Please follow the recommendations from your veterinarian.
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Genetic Information
This mutation was first described in a Jack Russell Terrier.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
CHRNE ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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