Congenital Myasthenic Syndrome, CMS
This condition is characterized by episodes of exercise intolerance and weakness.
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Signs and symptoms
Affected puppies can usually play or run for up to a half hour, after which their strides get progressively shorter and the dog collapses. After resting, dogs show no ill effects.
Signs first appear in puppies, typically between 3-5 months of age.Uncover health risks with Embark
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Diagnosis
Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.
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Treatment
CMS is a lifelong condition and their overall quality of life may be impacted. While some dogs with CMS lead relatively normal lives, the majority of puppies in this research study were euthanized.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s CMS result so you can plan appropriate monitoring and care.
- Avoid intense or prolonged exercise, as overexertion can worsen weakness or fatigue.
- Provide a calm, stable routine with gentle activity to help maintain mobility and prevent stress.
- With careful management and regular check-ins, many dogs with CMS can live comfortable lives.
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Genetic Information
This mutation was first described in Golden Retrievers.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
COLQ ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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