Copper Toxicosis (Attenuating)
This genetic variant may help lessen the effects of copper buildup in dogs that also carry the copper toxicosis risk variant ATP7B. On its own, it is not known to cause health problems.
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Signs and symptoms
There should be no clinical signs associated with this variant. This variant may help mitigate clinical signs in dogs with the ATP7B accumulating variant. If your dog has the ATP7B variant, please read about possible clinical signs on the ATP7B page.
A variant in this gene may delay or have no effect on the onset of clinical signs of copper toxicosis in dogs with the ATP7B variant. If your dog has the ATP7B variant, please read more about the age of onset on the ATP7B page.Uncover health risks with Embark
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Diagnosis
No diagnostics are required for this variant. If your dog has the ATP7B variant, please read what diagnostics may be considered on the ATP7B page.
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Treatment
No treatment is required for this variant. If your dog has the ATP7B variant, please read the available treatment on the ATP7B page.
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What to do if your dog is at risk
Actions
- No specific action is needed for dogs with this variant alone.
- If your dog also has the ATP7B variant, please review what actions you can take on the ATP7B page.
- Routine veterinary care and a balanced diet are appropriate for most dogs with this result.
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Genetic Information
This mutation was first described in the Labrador Retriever. However, it has recently been studied in the Doberman Pinscher and may also benefit this breed.
This variant has a X-linked complex inheritance. This variant has been shown to decrease copper accumulation in dogs with one or two copies of the ATP7B variant but is more effective in male dogs. However, this variant is not completely protective in either sex.
Gene names:
ATP7A ‐ chr
Inheritance type:
X-linked complex
Citations:
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Breeds affected
This health condition affects the following breeds
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