Cystinuria Type I-A
A disease of cystine accumulation, affected dogs are prone to developing cystine kidney and bladder stones. Fortunately, dogs with cystinuria maintain perfectly normal blood concentrations of cystine (unlike humans), and do not experience any ill effects from their disease besides stones.
-
Signs and symptoms
Affected dogs will show no clinical signs of disease in the early stages. As stones form, dogs will often urinate more frequently, urinate in inappropriate places, and possibly have blood in their urine. If a urinary obstruction forms, they are unable to urinate despite frequent straining. This is a medical emergency.
Signs typically develop in adult dogs when stones have had the chance to develop. -
Diagnosis
Genetic and laboratory testing are used to diagnose this condition.
-
Treatment
If caught early, Cystinuria can be managed with dietary changes, increased water intake, and certain medications. If stones develop, surgical removal is often necessary.
-
What to do if your dog is at risk
Actions
- Regular veterinary visits and laboratory testing will be vital to catching this disease in any early stage where it can be more easily managed.
- Closely monitor your dog for changes in their drinking and urination patterns.
-
Genetic Information
This mutation was first described in the Newfoundland.
This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.
Gene names:
SLC3A1 (Exon 2) ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
