Cystinuria Type II-B
A disease of cystine accumulation, affected dogs are prone to developing cystine kidney and bladder stones. Fortunately, dogs with cystinuria maintain perfectly normal blood concentrations of cystine (unlike humans), and do not experience any ill effects from their disease besides stones.
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Signs and symptoms
Affected dogs will show no clinical signs of disease in the early stages. As stones form, dogs will often urinate more frequently, urinate in inappropriate places, and possibly have blood in their urine. If a urinary obstruction forms, they are unable to urinate despite frequent straining. This is a medical emergency.
Signs typically develop in adult dogs when stones have had the chance to develop.Uncover health risks with Embark
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Diagnosis
Genetic and laboratory testing are used to diagnose this condition.
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Treatment
If caught early, Cystinuria can be managed with dietary changes, increased water intake, and certain medications. If stones develop, surgical removal is often necessary.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s cystinuria result so you can work together to plan ongoing care and monitoring.
- Schedule regular checkups and lab testing as recommended to detect any urinary changes early.
- Your vet may recommend a special diet to help reduce cystine levels and prevent urinary stone formation.
- Encourage your dog to drink plenty of water and watch for changes in urination, such as straining, accidents, or blood in the urine. Contact your vet if you notice any of these signs.
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Genetic Information
This mutation was first described in the Miniature Pinscher.
This mutation is inherited in an autosomal dominant manner, meaning that one or two copies of this gene will cause the disorder.
Gene names:
SLC7A9 (Exon 9) ‐ chr
Inheritance type:
dominant
Citations:
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Breeds affected
This health condition affects the following breeds
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