Ehlers-Danlos Syndrome (EDS)
Ehlers-Danlos Syndrome (EDS) is a disorder of collagen production leading to stretchy, hyperelastic skin and loose joints.
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Signs and symptoms
Affected puppies have very elastic and stretchy skin and hyper-mobile joints. They are injury prone and skin can be severely torn following even minor injuries.
Signs are first recognized in puppies. -
Diagnosis
Genetic testing, clinical signs, and skin biopsy can be used to diagnose this condition.
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Treatment
Unfortunately, there is no treatment for this condition.
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What to do if your dog is at risk
Actions
- Follow your veterinarian's recommendations and give any medications as prescribed.
- Try to minimize the potential for injury or trauma as much as possible.
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Genetic Information
This variant was first described in the Labrador Retriever. Genetic analysis of the parents confirmed this was a de novo mutation, which means that the mutation spontaneously occurred in this individual and was not inherited from the parents.
This variant is inherited in an autosomal dominant manner, meaning that a dog with one or two copies of the variant will show clinical signs.
Gene names:
COL5A1 Exon 34 ‐ chr
Inheritance type:
dominant
Citations:
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Breeds affected
This health condition affects the following breeds
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