Hemophilia A

Blood

Factor VIII deficiency (Hemophilia A) is a type of coagulopathy, a disorder of blood clotting. Dogs with this disorder can bleed spontaneously into their chest, abdomen, or joints. They will also develop significant bruising and profuse bleeding following a trauma or surgery.

  • Signs and symptoms

    Affected puppies may bleed abnormally when teething. You may notice extensive bruising or bleeding that does not stop following a traumatic event. If spontaneous bleeding occurs, you may notice that your dog has swollen joints, difficulty breathing, and/or a pendulous abdomen.

    This disease is typically diagnosed in puppies or young adults when they are spayed or neutered and have a problem with clotting. However, it can be diagnosed at any age.

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  • Diagnosis

    Genetic or laboratory tests are performed to diagnose this condition.

  • Treatment

    Currently, treatment for Hemophilia A focuses on prevention, vigilant monitoring, and quick treatment of spontaneous bleeds. Dogs with Hemophilia A are at great risk for uncontrollable bleeding during surgical procedures: your veterinarian should be informed so that appropriate blood products are at hand in case a transfusion is required. There is no definitive cure, though scientists have made progress correcting Hemophilia A with protein replacement and gene therapy in a laboratory setting.

  • What to do if your dog is at risk

    Actions

    • Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a catastrophic outcome.
    • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.

  • Genetic Information

    This variant was first identified in Boxers.

    Factor VIII deficiency has a sex-linked recessive inheritance pattern, which means that the gene is on the X chromosome. Females have two X chromosomes and must inherit two abnormal copies to be affected with this disease. Males have only one X chromosome and either have a normal copy of the gene or the mutation. If they have the mutation, they will have abnormal clotting.

    Gene names:

    F8 Exon 10 ‐ chrX

    Inheritance type:

    X-linked recessive

  • Breeds affected

    This health condition affects the following breeds

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