Factor XI Deficiency
Factor XI (FXI) Deficiency is an autosomally (not sex-linked) inherited blood clotting disorder and typically only causes a problem after surgery or trauma. Increased bleeding may be observed two to four days post-incident.
-
Signs and symptoms
After surgery or trauma, affected dogs may display bleeding or clotted blood (hematomas) around surgical sites, gastrointestinal bleeding, bruising of the skin, bloody urine, and/or nose bleeds. Increased bleeding or hematomas may not be observed until two to four days post-incident.
Factor XI Deficiency is typically diagnosed in puppies or young adults when they are spayed or neutered and have a problem with clotting. However, it can be diagnosed at any age.Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $118
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
A measure of Factor XI is the definitive diagnostic test, although levels vary significantly. Factor XI Deficiency is characterized by a normal prothrombin time (PT) and a prolonged activated partial thromboplastin time (APTT).
-
Treatment
Currently, Factor XI Deficiency cannot be treated, only managed. With proper care, dogs can have a normal lifespan with this condition despite increased blood clotting times. Veterinarians performing surgery on known affected dogs should have ready access to blood products banked for transfusions. However, the risk of bleeding from FXI Deficiency is lower than compared to some other factor deficiencies.
-
What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s genetic result, as it could impact upcoming surgeries or procedures.
- Be cautious with activities that could lead to injury, like rough play at dog parks or off-leash hikes.
- To help stop minor bleeding, such as from a broken nail, keep basic first-aid supplies on hand, including bandaging material and styptic powder.
- If your dog is injured, apply gentle pressure with gauze or a clean cloth to the wound. Keep your vet’s contact information handy in case the bleeding doesn’t stop within a few minutes.
-
Genetic Information
This variant was first described in the Kerry Blue Terrier.
This variant is inherited in an autosomal recessive manner, meaning a dog must have two copies of the variant to be affected by it.
Gene names:
F11 Exon 7 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
