Glanzmann's Thrombasthenia Type I


A disease of defective platelet aggregation, this causes affected dogs to bleed excessively in response to mild tissue trauma. Normally, platelets clump ("aggregate") together and form a plug at the site of injury. Dogs affected with Glanzmann’s thrombasthenia are unable to aggregate their platelets.

  • Signs and symptoms

    Affected dogs will bleed excessively when teething or from the nail quick if they are accidentally nicked during nail trimming. They will also bruise easily following even mild trauma. Spontaneous bleeding from the nose (epistaxis) or gums can also be observed.

    Signs develop during puppyhood and continue for the rest of the affected dog’s life.

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  • Diagnosis

    Genetic and laboratory testing are used to diagnose this condition.

  • Treatment

    There is no known treatment for this condition. Affected dogs may require blood products following trauma or surgery.

  • What to do if your dog is at risk


    • Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a catastrophic outcome.
    • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.

  • Genetic Information

    This disorder was first identified in the Great Pyrenees.

    This syndrome is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

    Gene names:

    ITGA2B Exon 13 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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