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Hematologic

This is a Blood condition.

Glanzmann's Thrombasthenia Type I

What is Glanzmann's Thrombasthenia Type I?

A disease of defective platelet aggregation, this causes affected dogs to bleed excessively in response to mild tissue trauma. Platelets are the first responders to tissue trauma: first, they clump together ("aggregate") by virtue of specific molecules in their membranes. They then puff up their membranes to become larger, leading to a secure platelet "plug" at the site of tissue injury. Dogs affected with Glanzmann’s thrombasthenia are unable to aggregate their platelets: this manifests as easy bruising (which you may not notice if your dog has dark skin) and excessive bleeding from the gums (especially if your pup likes to chew on rough bones or sticks) or from the nail quick if they are accidentally nicked during nail trimming.

What are the signs & symptoms that develop in affected dogs?

Affected dogs will bleed excessively when teething or from the nail quick if they are accidentally nicked during nail trimming. They will also bruise easily following even mild trauma. Spontaneous bleeding from the nose (epistaxis) or gums can also be observed.

When do signs and symptoms develop?

Signs develop during puppyhood and continue for the rest of the affected dog’s life.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnose this condition.

How is this condition treated?

There is no known treatment for this condition. Affected dogs may require blood products following trauma or surgery.

What actions should I take if my dog is affected?

Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a poor outcome. Be aware of the location of the nearest emergency veterinary hospital.

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