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Multisystem

This is a Multisystem condition.

Globoid Cell Leukodystrophy, Krabbe disease

What is Globoid Cell Leukodystrophy?

This lysosomal storage disease arises from buildup of certain lipid molecules, and can cause progressive neurologic signs. Affected dogs have an inappropriate buildup of modified lipids that lead to neurologic symptoms as young as 1 month of age. Usually, they come to the vet for failure to thrive and difficulty walking. Symptoms progress to include behavior changes, partial or complete blindness, generalized weakness, and seizures.

What are the signs & symptoms that develop in affected dogs?

Signs include weakness, partial or total vision loss, behavior changes, abnormal gait, and seizures.

When do signs and symptoms develop?

This is an early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as soon as 1 month of age.

How do vets diagnose this condition?

Genetic and laboratory testing used to diagnose this disease. Advanced imaging (MRI/CT) may be used to exclude other similar disease processes.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.

What actions should I take if my dog is affected?

Keeping your affected dog comfortable at home is the best therapy you can provide. Slings can be used to assist with their mobility. Blind dogs benefit from leaving your furniture in the same place and being put on leashes in unfamiliar territory. Please give your dog any medication as prescribed by your veterinarian.

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