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This is a Multisystem condition.

Globoid Cell Leukodystrophy, Krabbe disease

What is Globoid Cell Leukodystrophy?

This lysosomal storage disease arises from buildup of certain lipid molecules, and can cause progressive neurologic signs. Affected dogs have an inappropriate buildup of modified lipids that lead to neurologic symptoms as young as 1 month of age. Usually, they come to the vet for failure to thrive and difficulty walking. Symptoms progress to include behavior changes, partial or complete blindness, generalized weakness, and seizures.

What are the signs & symptoms that develop in affected dogs?

Signs include weakness, partial or total vision loss, behavior changes, abnormal gait, and seizures.

When do signs and symptoms develop?

This is an early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as soon as 1 month of age.

How do vets diagnose this condition?

Genetic and laboratory testing used to diagnose this disease. Advanced imaging (MRI/CT) may be used to exclude other similar disease processes.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.