This is a Multisystem condition.

Globoid Cell Leukodystrophy, Krabbe disease

What is Globoid Cell Leukodystrophy?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease is caused by buildup of certain lipid molecules, especially in cells of the nervous system.

What are the signs & symptoms that develop in affected dogs?

Signs include weakness, partial or total vision loss, behavior changes, abnormal gait, and seizures.

When do signs and symptoms develop?

This is an early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as soon as 1 month of age.

How do vets diagnose this condition?

Genetic and laboratory testing used to diagnose this disease. Advanced imaging (MRI/CT) may be used to exclude other similar disease processes.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.

What actions should I take if my dog is affected?

  • Keeping your affected dog comfortable at home is the best therapy you can provide.
  • Slings can be used to assist with their mobility.
  • Blind dogs benefit from leaving your furniture in the same place and being put on leashes in unfamiliar territory.
  • Please give your dog any medication as prescribed by your veterinarian.
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