Multisystem

This is a Multisystem condition.

Glycogen Storage Disease Type IIIA, GSD IIIA

What is GSD IIIA?

A mild, early onset form of glycogen storage disease, affected puppies often go to the vet for low energy levels and poor weight gain. Glycogen is the form in which our bodies store sugar: they are long, complex molecules that are primarily stored in the liver, heart, kidney, and muscle and are those tissues’ primary source of energy. In GSDs, glycogen accumulates to abnormal levels leading to enlargement and malfunction of these vital organs. Glycogen storage diseases (GSDs) occur in dogs, humans, and other animals. There are four types of GSDs known in dogs and these match Type I, II, IIIa and VII GSDs in humans. Dogs with Type III GSD show signs as puppies and usually have symptoms such as weight loss, failure to thrive, and mildly low levels of blood sugar.

What are the signs & symptoms that develop in affected dogs?

Affected dogs have "failure to thrive" including poor growth, lethargy, and mildly low blood sugars. They may be exercise intolerant and experience episodes of collapse.

When do signs and symptoms develop?

Signs appear around 14 months of age.

How do vets diagnose this condition?

Genetic and laboratory testing, including liver biopsy, are used to diagnose this disease.

How is this condition treated?

There is no treatment except supportive care for the clinical signs the affected dog develops.

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