Metabolic

This is a Metabolic condition.

Hypocatalasia, Acatalasemia

What is Hypocatalasia, Acatalasemia?

This condition causes no ill effects in the majority of dogs; however, some dogs can suffer from mouth ulcers leading to difficulty eating and increased susceptibility to oral infections. Catalase is important in fighting reactive oxygen species, which can cause cellular damage. Fortunately, many enzymes can break down reactive oxygen species; as such acatalasemia is usually a benign disease: however, some acatalasemic dogs suffer from what is known as Takahara’s disease, where patients have progressive mouth ulcers, which must be monitored closely and can be treated with soothing mouth sprays and washes as well as appropriate antibiotic therapy. Studies in humans and mice also indicate that acatalasemic individuals may have increased risk of developing Type II diabetes later in life; this can be monitored by routine checks of your dog's blood glucose.

What are the signs & symptoms that develop in affected dogs?

Most dogs show no clinical signs of this disease. Affected dogs can have oral ulcers and difficulty eating.

When do signs and symptoms develop?

This condition is most often diagnosed in adulthood.

How do vets diagnose this condition?

This condition is diagnosed through genetic testing. Oral disease can be diagnosed during a complete physical examination by your veterinarian. Some dogs require sedation for an oral exam due to pain.

How is this condition treated?

No treatment is required unless mouth ulcerations are present. Ulcerations cause an increased susceptibility to oral infections, which must be monitored closely. Treatment options include regular dental care, judicious use of antibiotics, and soothing mouth sprays and rinses.

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