Hypocatalasia, Acatalasemia


Catalase is important in fighting reactive oxygen species, which can cause cellular damage. Fortunately, many enzymes can break down reactive oxygen species; as such acatalasemia is usually a benign disease: however, some acatalasemic dogs suffer from what is known as Takahara’s disease, where patients have progressive mouth ulcers.

  • Signs and symptoms

    Most dogs show no clinical signs of this disease. Affected dogs can have oral ulcers and difficulty eating.

    This condition is most often diagnosed in adulthood.

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  • Diagnosis

    This condition is diagnosed through genetic testing. Oral disease can be diagnosed during a complete physical examination by your veterinarian. Some dogs require sedation for an oral exam due to pain.

  • Treatment

    No treatment is required unless mouth ulcerations are present. Ulcerations cause an increased susceptibility to oral infections, which must be monitored closely. Treatment options include regular dental care, judicious use of antibiotics, and soothing mouth sprays and rinses.

  • What to do if your dog is at risk


    • Please follow your veterinarian's advice to maintain your dog's dental health.

  • Genetic Information

    This mutation was first identified in a Beagle.

    Acatalasemia is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    CAT ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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