Junctional Epidermolysis Bullosa

skin & connective tissue

Junctional Epidermolysis Bullosa (JEB) is a hereditary blistering disease of the skin and mucous membranes, characterized by the spontaneous development of vesicles, erosions, and ulcers upon minimal trauma to the skin.

  • Signs and symptoms

    Affected dogs have skin and mucosal fragility resulting in blisters, deep erosions, and ulcers. Ulcers may occur in/on the mouth, lips, tongue, soft palate, throat, ears, digits, foot pads, elbows, ankles, knees, abdomen, groin, vulva/labia, penis/prepuce, and anus. The ulcers may ooze or be covered by crusts that can be bloody. Nails may be missing or misshapen. Affected dogs also have tooth enamel defects. Puppies may be underweight and display frequent choking while eating and drinking.

    Clinical signs begin at or soon after birth.

    Uncover health risks with Embark

    Embark Breed + Health Test

    Original price:


    Sale price:



    Embark for Breeders Dog DNA Test

    $129 - $159


  • Diagnosis

    Genetic testing, skin biopsy, and clinical signs can be used in conjunction with one another to diagnose Junctional Epidermolysis Bullosa. Clinical signs alone cannot reliably allow a veterinarian to differentiate between the three main subtypes of epidermolysis bullosa. For a more precise diagnosis, a microscopic evaluation of the tissue may be required.

  • Treatment

    Frank discussions about the quality of life are likely warranted. Owners typically request euthanasia by a few months of age due to the severity of the disease.

  • What to do if your dog is at risk


    • Monitor the dog closely and have them treated promptly for any injuries. Ulcerations of the skin and mucous membranes are painful and can become infected, so pain management and antibiotics may be needed.

  • Genetic Information

    This variant was first identified in the Australian Cattle Dog.

    JEB is inherited in an autosomal recessive manner, meaning a dog must have two copies of the variant to be affected by it.

    Gene names:

    LAMA3 Exon 66 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

Learn about your dog’s unique genetic health

Dog owners

Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.

Learn about the report for dog owners
Shop the test
Breeding programs

Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.

Learn about the report for breeders
Shop the test