Leonberger Polyneuropathy 2

Brain and Spinal Cord

LPN2 is a non-painful neurodegenerative condition leading to gradual muscle atrophy. LPN2 has been compared to the human condition Charcot-Marie-Tooth Disease.

  • Signs and symptoms

    This can cause signs of weakness, laryngeal paralysis, and difficulty breathing. Dogs affected as young adults will often have more severe signs.

    Development of signs is widely variable, from several months to 11 years of age.

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  • Diagnosis

    Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.

  • Treatment

    There is no treatment for this disorder. Certain medications may be prescribed to control symptoms.

  • What to do if your dog is at risk


    • Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.

  • Genetic Information

    This mutation was first described in the Leonberger.

    This disease is inherited in an autosomal dominant manner, meaning that only one copy of the mutation is necessary to show signs of the disease. However, this mutation has incomplete penetrance, meaning that not all dogs that carry the mutation will show signs of the disease.

    Gene names:

    GJA9 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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