Laryngeal Paralysis and Polyneuropathy
Laryngeal paralysis and polyneuropathy is a condition where a dog's larynx (voice box) doesn't function properly, and they can have difficulty breathing and vocalizing. There are multiple genetic variants that can potentially cause this disorder.
-
Signs and symptoms
Most dogs with laryngeal paralysis and polyneuropathy have noisy or raspy breathing, changes in barking, and do not tolerate exercise. Some dogs can have difficulty walking, uncoordinated motion, and muscle weakness.
The age of onset varies by breed. In Leonbergers, the average age of onset was 3.4 years. In Saint Bernards, the average was 2.1 years. Labrador Retrievers' average age was 7.5 years (Letko, 2020).Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $125
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
Diagnosis is made based on history and physical examination of the function of the larynx, which is typically performed with sedation.
-
Treatment
Treatment is aimed at reducing episodes of respiratory distress and environmental modification. Some dogs may be candidates for the surgical opening of the larynx (often referred to as a “tie-back”). However, there is an increased risk of aspiration pneumonia after the procedure.
-
What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s polyneuropathy result so you can plan ongoing care and monitoring.
- Watch for signs such as voice changes, noisy breathing, weakness, or difficulty swallowing, and contact your vet if you notice any of these.
- Maintain your dog at a healthy weight and keep them in a calm environment. Avoid strenuous exercise or overheating, as these can worsen breathing problems.
- As this condition can progress over time, supportive care and a safe, predictable routine can help keep your dog comfortable and engaged with their family.
-
Genetic Information
This variant was first identified in the Saint Bernard, Labrador Retriever, and Leonberger.
The publication reports that 4.1% of Leonbergers with unexplained laryngeal paralysis had two copies of this variant. In Saint Bernards, 41.6% of diagnosed dogs had two copies of the variant. In Labrador Retrievers, 4.7% of diagnosed dogs had two copies of this variant. The variant was also found in at least 25 different breeds, but the clinical impact in those breeds is unknown (Letko, 2020).
Gene names:
CNTNAP1 Exon 18 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
