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Hematologic

This is a Blood condition.

Ligneous Membranitis, LM

What is LM?

A rare chronic disease that affects the delicate lining of the nostrils, mouth, throat, and eyelids.Eventually the chronic inflammation leads to thickening and scarring of the affected tissues. The same processes can affect the inner linings of the heart and central nervous system, which can lead to permanent heart and brain damage. LM is caused by a mutation in the gene coding for plasminogen, which plays an important role in dissolving fibrin blood clots.

What are the signs & symptoms that develop in affected dogs?

Affected dogs often have chronic nasal discharge, conjunctivitis, and coughing.

When do signs and symptoms develop?

Signs typically develop in puppies.

How do vets diagnose this condition?

Genetic and laboratory testing along with clinical signs are used to diagnose this disease.

How is this condition treated?

LM is a devastating disease and requires aggressive and continuous replacement of plasminogen with medically available blood products. Euthanasia is often elected.

What actions should I take if my dog is affected?

  • Currently, there are no actions you can take at home to alter this disease.
  • Talk with your veterinarian about diagnostic and monitoring steps that you can take together.