Lundehund Syndrome

Gastrointestinal

Norwegian Lundehunds are known to have stomach and intestinal problems collectively known as Lundehund Syndrome. This genetic mutation affects neuroendocrine cells in the intestinal tract and is thought to be similar to inflammatory bowel disease.

  • Signs and symptoms

    Affected dogs will have moderate to severe clinical signs including vomiting, diarrhea, weight loss, and hair loss. Fluid retention in the legs (edema) and fluid in the abdomen (ascites) can also be seen.

    Signs can first appear in a wide range of ages - from approximately 2 to 10 years of age.

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  • Diagnosis

    Genetic testing, blood work, abdominal ultrasound, and surgical biopsy are all used to diagnose this condition.

  • Treatment

    At this time, treatment is symptomatic. In very severe cases with a poor response to therapy, euthanasia is considered.

  • What to do if your dog is at risk

    Actions

    • Talk to your vet about your dog’s Lundehund syndrome result so you can plan an appropriate diet and regular monitoring.
    • Follow your vet’s nutritional recommendations closely, as special diets can help manage digestive symptoms and nutrient absorption.
    • Watch for signs such as diarrhea, vomiting, weight loss, or loss of appetite, and contact your vet if you notice these.
    • With consistent care and monitoring, many dogs with this condition can live relatively normal, comfortable lives.

  • Genetic Information

    This mutation was first described in Norwegian Lundehunds.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    LEPREL1 ‐ chr

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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