Lundehund Syndrome


Norwegian Lundehunds are known to have stomach and intestinal problems collectively known as Lundehund Syndrome. This genetic mutation affects neuroendocrine cells in the intestinal tract and is thought to be similar to inflammatory bowel disease.

  • Signs and symptoms

    Affected dogs will have moderate to severe clinical signs including vomiting, diarrhea, weight loss, and hair loss. Fluid retention in the legs (edema) and fluid in the abdomen (ascites) can also be seen.

    Signs can first appear in a wide range of ages - from approximately 2 to 10 years of age.

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  • Diagnosis

    Genetic testing, blood work, abdominal ultrasound, and surgical biopsy are all used to diagnose this condition.

  • Treatment

    At this time, treatment is symptomatic. In very severe cases with a poor response to therapy, euthanasia is considered.

  • What to do if your dog is at risk


    • Please consult your veterinarian for dietary advice, therapeutic prescriptions and periodic monitoring.

  • Genetic Information

    This mutation was first described in Norwegian Lundehunds.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    LEPREL1 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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