Malignant Hyperthermia


This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in body temperature (hyperthermia).

  • Signs and symptoms

    Affected dogs under anesthesia will have an extreme spike in body temperature and uncontrollable muscle contractions.

    Signs only appear when a dog is placed under certain anesthetics.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    This can be life threatening. Emergency treatment includes removal of the inhalant anesthetic and rapid cooling of the body with ice and fans.

  • What to do if your dog is at risk


    • By testing your dog for the mutation that causes malignant hyperthermia, you and your veterinarian can consult to best treat your dog should he or she require anesthesia.

  • Genetic Information

    This mutation was first described in a mixed breed dog living in a university breeding colony.

    This mutation is inherited in an autosomal dominant manner, meaning that one or two copies of this gene will cause the disorder.

    Gene names:

    RYR1 ‐ chr1

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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