Medium-Chain Acyl-CoA Dehydrogenase Deficiency, MCADD
Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) affects the body's ability to break down certain fats for energy. This can lead to lethargy and seizures in affected dogs.
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Signs and symptoms
Affected dogs are often lethargic for long periods and may have seizures.
The age of diagnosis can vary, but signs typically first appear in young dogs. -
Diagnosis
A combination of physical examination, blood tests, and genetic testing can be used to diagnose MCADD.
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Treatment
Treatment consists of frequent feeding of low-fat diets. Anti-convulsant therapy may be indicated in some cases.
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What to do if your dog is at risk
Actions
- Frequent feedings are required to prevent affected dogs from entering a fasted state where they must rely on their fat storage for energy.
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Genetic Information
This variant was first described in the Cavalier King Charles Spaniel.
This variant is inherited in an autosomal recessive manner, meaning a dog requires two copies of the variant to show signs of MCADD.
Gene names:
ACADM ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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