Medium-Chain Acyl-CoA Dehydrogenase Deficiency, MCADD


Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) affects the body's ability to break down certain fats for energy. This can lead to lethargy and seizures in affected dogs.

  • Signs and symptoms

    Affected dogs are often lethargic for long periods and may have seizures.

    The age of diagnosis can vary, but signs typically first appear in young dogs.

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  • Diagnosis

    A combination of physical examination, blood tests, and genetic testing can be used to diagnose MCADD.

  • Treatment

    Treatment consists of frequent feeding of low-fat diets. Anti-convulsant therapy may be indicated in some cases.

  • What to do if your dog is at risk


    • Frequent feedings are required to prevent affected dogs from entering a fasted state where they must rely on their fat storage for energy.

  • Genetic Information

    This variant was first described in the Cavalier King Charles Spaniel.

    This variant is inherited in an autosomal recessive manner, meaning a dog requires two copies of the variant to show signs of MCADD.

    Gene names:

    ACADM ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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