Methemoglobinemia
Oxygen is carried in the blood by hemoglobin. Methemoglobin forms when hemoglobin iron is oxidized, and it cannot carry oxygen in the blood. Methemoglobinemia is a disease where too much methemoglobin is present and the body no longer has the oxygen supply it needs to function. This disease was first described in a mixed breed dog.
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Signs and symptoms
Your dog may have a rapid respiratory rate, blue gums, and have exercise intolerance.
Signs often first appear with a concurrent disease, such as a respiratory infection, that causes affected dogs to decompensate. -
Diagnosis
Genetic and laboratory testing can be used to diagnose this condition. Please note that there are also toxins that can cause this condition.
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Treatment
Methylene blue can be administered to control the clinical signs, however, this is not a cure and is a long term therapy. Treatment of concurrent infections or inflammation is also recommended.
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What to do if your dog is at risk
Actions
- Please see your veterinarian as soon as possible if you suspect a respiratory infection or any other breathing difficulties as these can become life threatening if not addressed.
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Genetic Information
This disease was first described in a mixed breed dog.
This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.
Gene names:
CYB5R3 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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