Methemoglobinemia is a blood disorder where too much methemoglobin is present. This protein affects how the blood carries oxygen, meaning that the body does not have enough oxygen supply.

  • Signs and symptoms

    Your dog may have a rapid respiratory rate, blue gums, and exercise intolerance.

    Signs of methemoglobinemia often first appear with an associated disease, such as a respiratory infection.

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  • Diagnosis

    Genetic and laboratory testing can be used to diagnose this condition. Please note that there are also toxins that can cause this condition.

  • Treatment

    Methylene blue can be administered to control the clinical signs. However, this is a long-term therapy, not a cure. Treatment of concurrent infections or inflammation is also recommended.

  • What to do if your dog is at risk


    • Please see your veterinarian as soon as possible if you suspect a respiratory infection or any other breathing difficulties, as these can become life-threatening if not addressed.

  • Genetic Information

    This variant was first described in the Pit Bull Terrier.

    This variant is inherited in an autosomal dominant manner, meaning that a dog only requires one copy of the variant to show clinical signs of methemoglobinemia.

    Gene names:

    CYB5R3 Exon 7 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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