Muscular Dystrophy-Dystroglycanopathy


Muscular dystrophy-dystroglycanopathy is characterized by muscle weakness and loss with possible brain and heart abnormalities. Puppies with this condition have poor rates of growth and difficulty suckling or eating.

  • Signs and symptoms

    Affected puppies are smaller than their littermates and have a poor suckling reflex. They are noticeably weaker, and their stance tends to be bow-legged.

    Signs develop shortly after birth. In the litter where the variant was discovered, the puppies were humanely euthanized between 2.5 and 6 weeks of age.

    Uncover health risks with Embark

    Embark Breed + Health Test

    Original price:


    Sale price:



    Embark for Breeders Dog DNA Test

    $129 - $159


  • Diagnosis

    Diagnosis includes a physical exam, genetic testing, blood work, and muscle biopsy with special staining.

  • Treatment

    Unfortunately, there is no treatment for this condition, and puppies are often euthanized at a young age.

  • What to do if your dog is at risk


    • Keeping affected puppies comfortable and monitoring their quality of life are the only actions that can currently be taken.

  • Genetic Information

    This variant was first described in the Labrador Retriever.

    This variant is inherited in an autosomal recessive manner, meaning that a dog requires two copies of the variant to show signs of muscular dystrophy-dystroglycanopathy.

    Gene names:

    LARGE1 Exon 11 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

Learn about your dog’s unique genetic health

Dog owners

Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.

Learn about the report for dog owners
Shop the test
Breeding programs

Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.

Learn about the report for breeders
Shop the test