Musladin-Lueke Syndrome, MLS
This condition causes abnormally strong connections between the structural proteins that provide strength and integrity to tissues like the skin and skeletal muscle, as well as the protective tissue sheaths of the bones and central nervous system.
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Signs and symptoms
Dogs with MLS typically come to the vet because of severely contracted joints that cause them to walk on their toes, rather than their paw pads. However, due to the effect of the mutation on internal connective tissues, some dogs can also experience seizures.
Signs are often first recognized in puppies. -
Diagnosis
Clinical signs, genetic testing, and biopsy can be used to diagnose this condition.
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Treatment
Unfortunately, there is no treatment for MLS. However, all but most severe cases can be managed with supportive care.
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What to do if your dog is at risk
Actions
- Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.
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Genetic Information
This mutation was first described in the Beagle.
This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.
Gene names:
ADAMTSL2 (Exon 7) ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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