Myasthenia Gravis-Like Syndrome

Neuromuscular

This condition causes progressive muscle weakness that worsens with activity. Puppies may seem stronger in the morning but become increasingly tired or weak by evening, sometimes displaying decreased reflexes or collapsing.

  • Signs and symptoms

    Affected puppies had poor coordination, decreased reflexes and collapse.

    Signs first appear in young puppies.

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  • Diagnosis

    Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.

  • Treatment

    This is a lifelong condition that showed poor response to medical treatments.

  • What to do if your dog is at risk

    Actions

    • Talk to your vet about your dog’s myasthenia gravis–like syndrome result so you can plan appropriate monitoring and care.
    • Avoid known triggers such as overexertion, stress, or excitement, which can worsen muscle weakness.
    • Watch for signs like a drooping head, difficulty walking, or changes in swallowing, and contact your vet if you notice them.
    • With consistent management and a calm, predictable routine, many dogs with this condition can remain comfortable and active.

  • Genetic Information

    This mutation was first described in the Heideterrier.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    CHRNE ‐ chr

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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