Myasthenia Gravis-Like Syndrome


This is a disease characterized by progressive weakness, with puppies being more active in the morning and progressively weaker by night. Puppies also exhibited decreased reflexes and collapse.

  • Signs and symptoms

    Affected puppies had poor coordination, decreased reflexes and collapse.

    Signs first appear in young puppies.

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  • Diagnosis

    Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.

  • Treatment

    This is a lifelong condition that showed poor response to medical treatments.

  • What to do if your dog is at risk


    • Minimizing exposure to typical triggers may help reduce clinical signs. Please follow the recommendations from your veterinarian.

  • Genetic Information

    This mutation was first described in the Heideterrier.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

    Gene names:

    CHRNE ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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