Nemaline Myopathy
Named for the thread-like inclusions seen on microscopic examination of affected muscle samples, Nemaline Myopathy (NM) causes generalized skeletal muscle weakness.
-
Signs and symptoms
Affected dogs may show non-progressive generalized muscle weakness, decreased muscle tone (hypotonia), exercise intolerance, and tremors. Chronic cases can also present with lethargy, reduced appetite, abdominal distension, and muscle wasting.
Affected dogs may begin displaying signs as early as two months of age.Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $139
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
Diagnosis is made based on clinical history, physical examination, laboratory values, and genetic testing. Rod bodies in a skeletal muscle biopsy, elevated creatine kinase (CK) in serum, and changes to electromyography (EMG) and motor nerve conduction velocity (MNCV) testing results may be observed.
-
Treatment
There is no cure for NM; all currently available treatments are symptomatic or supportive in nature.
-
What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s nemaline myopathy result so you can plan appropriate monitoring and supportive care.
- Provide a calm environment and use slings or harnesses to assist with mobility and prevent falls.
- Soft bedding and nonslip flooring can help your dog rest comfortably and move around more safely.
- Gentle, low-impact activities and predictable routines can help keep your dog engaged and maintain muscle strength as long as possible.
-
Genetic Information
This variant was first described in American Bulldogs.
Nemaline Myopathy is recessive, that is, a dog requires two copies of the variant to show signs of the disease from the variant.
Gene names:
NEB ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
