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Muscular

This is a Muscular condition.

Nemaline Myopathy

What is Nemaline Myopathy?

Named for the thread-like inclusions seen on microscopic examination of affected muscle samples, Nemaline Myopathy (NM) causes generalized skeletal muscle weakness.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may show non-progressive generalized muscle weakness, decreased muscle tone (hypotonia), exercise intolerance, and tremors. Chronic cases can also present with lethargy, reduced appetite, abdominal distension, and muscle wasting.

When do signs and symptoms develop?

Affected dogs may begin displaying signs as early as two months of age.

How do vets diagnose this condition?

Diagnosis is made based on clinical history, physical examination, laboratory values, and genetic testing. Rod bodies in a skeletal muscle biopsy, elevated creatine kinase (CK) in serum, and changes to electromyography (EMG) and motor nerve conduction velocity (MNCV) testing results may be observed.

How is this condition treated?

There is no cure for NM; all currently available treatments are symptomatic or supportive in nature.

What actions should I take if my dog is affected?

  • Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.
  • Slings can be used to assist with their mobility, and caution should be taken to avoid falling hazards.