Oculoskeletal Dysplasia 2

Skeletal

This is a developmental disease that causes dwarfism, lameness, and partial to complete vision loss.

  • Signs and symptoms

    Signs can include dramatic short-limbed dwarfism, lameness, and partial to complete vision loss. Affected dogs tend to have early onset arthritis.

    Signs are first recognized in puppies.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Currently, there is no treatment for this condition. Medications may be prescribed to help with pain.

  • What to do if your dog is at risk

    Actions

    • Talk to your vet about your dog’s OSD2 result so you can discuss whether any signs are present and plan care if needed.
    • Some dogs show only mild limb shortening and live normal, active lives, while others may need extra support for mobility or vision changes.
    • Provide soft bedding, nonslip flooring, and ramps if your dog has trouble getting around, and avoid activities like jumping or climbing stairs that could stress the joints.
    • If you notice signs of vision loss, keep your dog on a leash in unfamiliar areas and use verbal cues to help them navigate safely.

  • Genetic Information

    This mutation was first described in the Samoyed.

    This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

    Gene names:

    COL9A2 (5' UTR) ‐ chr

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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