P2Y12 Receptor Platelet Disorder
This condition affects how blood platelets clump together, so bleeding may be heavier than expected after surgery or injury. Spontaneous bleeding is uncommon, but planning ahead for procedures is important.
-
Signs and symptoms
Affected puppies may bleed abnormally when teething. You may notice extensive bruising or bleeding that does not stop following a traumatic event.
Signs may occur at any age but are most often recognized in young dogs during an elective surgery or following a trauma.Uncover health risks with Embark
Embark Breed + Health Test
- Regular Price
$199
- Sale Price
- $130
Embark for Breeders dog DNA test kits
- Sale Price
- $119-$139 per test
-
Diagnosis
Genetic or laboratory testing is necessary to diagnose P2Y12 deficiency. If you have a Greater Swiss Mountain Dog, you should absolutely test them for this disorder prior to surgery.
-
Treatment
Currently there is no treatment for this disorder. If your dog must have surgery, your veterinarian should be prepared to provide multiple transfusions during and/or after the procedure.
-
What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s genetic result, as it could impact upcoming surgeries or procedures.
- Be cautious with activities that could lead to injury, like rough play at dog parks or off-leash hikes.
- To help stop minor bleeding, such as from a broken nail, keep basic first-aid supplies on hand, including bandaging material and styptic powder.
- If your dog is injured, apply gentle pressure with gauze or a clean cloth to the wound. Keep your vet’s contact information handy in case the bleeding doesn’t stop within a few minutes.
-
Genetic Information
This mutation was first identified in a Greater Swiss Mountain Dog that bled significantly following a spay. The disease arises from a mutation in the P2Y12 gene, which is required for platelets to aggregate and form the protective platelet "plug" in the event of tissue injury.
P2Y12 deficiency is inherited in an autosomal recessive manner, meaning that a dog must possess two copies of the mutation to show clinical signs of the disease.
Gene names:
P2Y12 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
