P2Y12 Receptor Platelet Disorder


P2Y12 deficiency is a coagulopathy, or disorder of blood clotting, which affects platelet function. This mutation does not cause spontaneous bleeding but will cause excessive bleeding following a trauma or surgery.

  • Signs and symptoms

    Affected puppies may bleed abnormally when teething. You may notice extensive bruising or bleeding that does not stop following a traumatic event.

    Signs may occur at any age but are most often recognized in young dogs during an elective surgery or following a trauma.

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  • Diagnosis

    Genetic or laboratory testing is necessary to diagnose P2Y12 deficiency. If you have a Greater Swiss Mountain Dog, you should absolutely test them for this disorder prior to surgery.

  • Treatment

    Currently there is no treatment for this disorder. If your dog must have surgery, your veterinarian should be prepared to provide multiple transfusions during and/or after the procedure.

  • What to do if your dog is at risk


    • Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a catastrophic outcome.
    • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.

  • Genetic Information

    This mutation was first identified in a Greater Swiss Mountain Dog that bled significantly following a spay. The disease arises from a mutation in the P2Y12 gene, which is required for platelets to aggregate and form the protective platelet "plug" in the event of tissue injury.

    P2Y12 deficiency is inherited in an autosomal recessive manner, meaning that a dog must possess two copies of the mutation to show clinical signs of the disease.

    Gene names:

    P2Y12 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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