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Neuromuscular

This is a Neuromuscular condition.

Paroxysmal Dyskinesia, PxD

What is PxD?

Paroxysmal Dyskinesia is a neurologic condition that causes dogs to have episodes where their movement is very abnormal, especially in their hind legs. This disease is easily confused with a seizure disorder. It is suspected to be a malfunction in the basal nuclei, which control movement in the brain. This mutation was first described in Soft Coated Wheaten Terriers. This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs. Signs typically first appear in young adults. Affected dogs may have dystonia (uncontrollable muscle contractions) and muscle spasms multiple times a day. However, the affected dog will appear clinically normal between episodes. Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition. There is no treatment for this condition, however, anti-seizure medications are sometimes prescribed. These may or may not improve clinical signs. Excitement appears to be a trigger, so keeping your dog on a predictable routine may be of some benefit.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have dystonia (uncontrollable muscle contractions) and muscle spasms multiple times a day. However, the affected dog will appear clinically normal between episodes.

When do signs and symptoms develop?

Signs typically first appear in young adults.

How do vets diagnose this condition?

Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.

How is this condition treated?

There is no treatment for this condition, however, anti-seizure medications are sometimes prescribed. These may or may not improve clinical signs.

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