Prekallikrein Deficiency
Prekallikrein is an enzyme necessary for the activation of certain clotting proteins. Fortunately, this is a benign blood disorder and is not associated with increased bleeding tendencies.
-
Signs and symptoms
Affected dogs have abnormally long clotting times on laboratory coagulation tests, but this does not lead to an increased bleeding risk clinically.
Dogs are born with this disorder, but it is often not recognized unless your veterinarian performs certain blood tests. -
Diagnosis
Genetic testing and laboratory clotting times are used to diagnose this condition.
-
Treatment
At this time, no treatment is required for dogs with this genetic mutation.
-
What to do if your dog is at risk
Actions
- Genetic testing for this benign disorder saves you (and your dog) the time and money that these diagnostics would require.
-
Genetic Information
This mutation was first identified in a Shih Tzu.
Dogs must have two copies of the mutation for their prekallikrein levels to be affected.
Gene names:
KLKB1 Exon 8 ‐ chr
Inheritance type:
recessive
Citations:
-
Breeds affected
This health condition affects the following breeds
Learn about your dog’s unique genetic health
Dog owners
Breed identification, health and trait insights, personalized care recommendations, and the world’s first canine relative finder—all in one leading dog DNA test.
Learn about the report for dog ownersShop the test
Breeding programs
Embark’s test for breeding programs is one comprehensive DNA test designed with your needs in mind.
Learn about the report for breedersShop the test
